Acquired antithrombin deficiency is a risk factor for venous thromboembolism after major trauma.

ABSTRACT:

Background

Up to 30% of severely injured patients on prophylactic anticoagulation experience venous thromboembolism (VTE). Our previous work shows that acquired antithrombin (AT) deficiency [AT<80%] occurs in approximately 20% of trauma patients upon admission and drives poor responsiveness to enoxaparin. However, changes in AT over time and its association with VTE remain unknown. The aim of this study was to determine the relationship between acquired AT deficiency and VTE in severely injured patients.

Methods

A secondary analysis of the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) clinical trial was performed. Patients who died within 24 h of hemorrhage were excluded from analysis. Demographics, mechanism and severity of injury, transfusions volumes,

SUBMITTER: Rahbar E 

PROVIDER: S-EPMC9653093 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature