Association of hyperglycemia and molecular subclass on survival in IDH-wildtype glioblastoma.

ABSTRACT:

Background

Hyperglycemia has been associated with worse survival in glioblastoma. Attempts to lower glucose yielded mixed responses which could be due to molecularly distinct GBM subclasses.

Methods

Clinical, laboratory, and molecular data on 89 IDH-wt GBMs profiled by clinical next-generation sequencing and treated with Stupp protocol were reviewed. IDH-wt GBMs were sub-classified into RTK I (Proneural), RTK II (Classical) and Mesenchymal subtypes using whole-genome DNA methylation. Average glucose was calculated by time-weighting glucose measurements between diagnosis and last follow-up.

Results

Patients were stratified into three groups using average glucose: tertile one (<100 mg/dL), tertile two (100-115 mg/dL), and tertile three (>115 mg/dL). Comparison across gl

SUBMITTER: Liu EK 

PROVIDER: S-EPMC9653172 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature