Neurophysiological correlates of cognitive control and approach motivation abnormalities in adolescent bipolar disorders.

ABSTRACT: Hypersensitivity to reward-relevant stimuli is theorized to be a core etiological factor in bipolar disorders (BDs). However, little is known about the role of cognitive control dysregulation within reward contexts in BDs, particularly during adolescence. Using electroencephalography (EEG), we explored alterations in cognitive control processes and approach motivation in 99 adolescents with (n=53) and without (n=46) BD during reward striving (target anticipation) and reward attainment (feedback) phases of a monetary incentive delay (MID) task. Time-frequency analysis yielded frontal theta and frontal alpha asymmetry as indices of cognitive control and approach motivation, respectively. Multilevel mixed models examined group differences, as well as age, sex, and other effects, on frontal th

SUBMITTER: Maresh EL 

PROVIDER: S-EPMC9653266 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature