Interaction of childhood abuse and depressive symptoms on cortical thickness: a general population study.

ABSTRACT: Childhood abuse was inconsistently related to whole-brain cortical thickness in former studies. However, both childhood abuse and cortical thickness have been associated with depressive symptoms. We hypothesised that childhood abuse moderates the association between depressive symptoms and cortical thickness. In 1551 individuals of the general population, associations between whole-brain cortical thickness and the interaction of childhood abuse (emotional, physical, and sexual) and depressive symptoms were analysed using an ANCOVA. Linear regression analyses were used to estimate the same effect on the cortical thickness of 34 separate regions (Desikan-Killiany-atlas). A significant interaction effect of childhood abuse and depressive symptoms was observed for whole-brain cortical thicknes

SUBMITTER: Voss S 

PROVIDER: S-EPMC9653317 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature