Assessment of structural disconnections in gliomas: comparison of indirect and direct approaches.

ABSTRACT: Gliomas are amongst the most common primary brain tumours in adults and are often associated with poor prognosis. Understanding the extent of white matter (WM) which is affected outside the tumoral lesion may be of paramount importance to explain cognitive deficits and the clinical progression of the disease. To this end, we explored both direct (i.e., tractography based) and indirect (i.e., atlas-based) approaches to quantifying WM structural disconnections in a cohort of 44 high- and low-grade glioma patients. While these methodologies have recently gained popularity in the context of stroke and other pathologies, to our knowledge, this is the first time they are applied in patients with brain tumours. More specifically, in this work, we present a quantitative comparison of the disconnec

SUBMITTER: Silvestri E 

PROVIDER: S-EPMC9653324 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature