Characterization of structural and functional network organization after focal prefrontal lesions in humans in proof of principle study.

ABSTRACT: Lesion research classically maps behavioral effects of focal damage to the directly injured brain region. However, such damage can also have distant effects that can be assessed with modern imaging methods. Furthermore, the combination and comparison of imaging methods in a lesion model may shed light on the biological basis of structural and functional networks in the healthy brain. We characterized network organization assessed with multiple MRI imaging modalities in 13 patients with chronic focal damage affecting either superior or inferior frontal gyrus (SFG, IFG) and 18 demographically matched healthy Controls. We first defined structural and functional network parameters in Controls and then investigated grey matter (GM) and white matter (WM) differences between patients and Controls

SUBMITTER: Noonan MP 

PROVIDER: S-EPMC9653359 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature