FAAH polymorphism (rs324420) modulates extinction recall in healthy humans: an fMRI study.

ABSTRACT: Gold standard treatments for anxiety- and trauma-related disorders focus on exposure therapy promoting extinction learning and extinction retention. However, its efficacy is limited. Preclinical and particularly animal research has been able to demonstrate that homozygosity for the fatty acid amide hydrolase (FAAH) C385A allele, similar to FAAH inhibition, is associated with elevated concentrations of anandamide (AEA) and facilitates extinction learning and extinction recall. However, in humans, the underlying neurobiological processes are less well understood, and further knowledge might enhance the development of more effective therapies. In this functional magnetic resonance imaging (fMRI) study, a fear conditioning, fear extinction and extinction recall paradigm was conducted with 55 h

SUBMITTER: Spohrs J 

PROVIDER: S-EPMC9653364 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature