Lipid-mediated prestin organization in outer hair cell membranes and its implications in sound amplification.

ABSTRACT: Prestin is a high-density motor protein in the outer hair cells (OHCs), whose conformational response to acoustic signals alters the shape of the cell, thereby playing a major role in sound amplification by the cochlea. Despite recent structures, prestin's intimate interactions with the membrane, which are central to its function remained unresolved. Here, employing a large set (collectively, more than 0.5 ms) of coarse-grained molecular dynamics simulations, we demonstrate the impact of prestin's lipid-protein interactions on its organization at densities relevant to the OHCs and its effectiveness in reshaping OHCs. Prestin causes anisotropic membrane deformation, which mediates a preferential membrane organization of prestin where deformation patterns by neighboring copies are aligned co

SUBMITTER: Dehghani-Ghahnaviyeh S 

PROVIDER: S-EPMC9653410 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature