Neurotoxicity of diesel exhaust extracts in zebrafish and its implications for neurodegenerative disease.

ABSTRACT: Long-term air pollution (AP) exposure, including diesel exhaust exposure, is increasingly being recognized as a major contributor to the development of neurodegenerative diseases such as Parkinson's and Alzheimer's disease. How AP increases the risk of neurodegeneration is not well understood but might include direct neurotoxicity and CNS inflammation. We investigated the impact of diesel exhaust particulate extract (DEPe) exposure on the brain and the mechanisms by which microglia and astroglia might mediate neuronal changes. Zebrafish (ZF) were utilized to determine neuronal toxicity of and microglial response to DEPe and single cell RNA sequencing was employed to study cell type-specific transcriptomic responses within the ZF brain. DEPe exposure induced neuronal injury and microglial a

SUBMITTER: Ha SM 

PROVIDER: S-EPMC9653411 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature