Transcriptomic analysis reveals an association of FCGBP with Parkinson's disease.

ABSTRACT: Transcriptomics in Parkinson's disease (PD) offers new insights into the molecular mechanism of PD pathogenesis. Several pathways, such as inflammation and protein degradation, have been identified by differential gene expression analysis. Our aim was to identify gene expression differences underlying the disease etiology and the discovery of pre-symptomatic risk biomarkers for PD from a multicenter study in the context of the PROPAG-AGEING project. We performed RNA sequencing from 47 patients with de novo PD, 10 centenarians, and 65 healthy controls. Using identified differentially expressed genes, functional annotations were assigned using gene ontology to unveil significant enriched biological processes. The expression of 16 selected genes was validated using OpenArray® assays and sampl

SUBMITTER: Gomez-Garre P 

PROVIDER: S-EPMC9653420 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature