Ligand-enabled Ni-catalyzed hydroarylation and hydroalkenylation of internal alkenes with organoborons.

ABSTRACT: The transition metal-catalyzed hydrofunctionalization of alkenes offers an efficient solution for the rapid construction of complex functional molecules, and significant progress has been made during last decades. However, the hydrofunctionalization of internal alkenes remains a significant challenge due to low reactivity and the difficulties of controlling the regioselectivity. Here, we report the hydroarylation and hydroalkenylation of internal alkenes lacking a directing group with aryl and alkenyl boronic acids in the presence of a nickel catalyst, featuring a broad substrate scope and wide functional group tolerance under redox-neutral conditions. The key to achieving this reaction is the identification of a bulky 1-adamantyl β-diketone ligand, which is capable of overcoming the low r

SUBMITTER: Wang DM 

PROVIDER: S-EPMC9653468 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature