Association between vitamin D supplementation and COVID-19 infection and mortality.

ABSTRACT: Vitamin D deficiency has long been associated with reduced immune function that can lead to viral infection. Several studies have shown that Vitamin D deficiency is associated with increases the risk of infection with COVID-19. However, it is unknown if treatment with Vitamin D can reduce the associated risk of COVID-19 infection, which is the focus of this study. In the population of US veterans, we show that Vitamin D₂ and D₃ fills were associated with reductions in COVID-19 infection of 28% and 20%, respectively [(D₃ Hazard Ratio (HR) = 0.80, [95% CI 0.77, 0.83]), D₂ HR = 0.72, [95% CI 0.65, 0.79]]. Mortality within 30-days of COVID-19 infection was similarly 33% lower with Vitamin D₃ and 25% lower with D₂ (D₃

SUBMITTER: Gibbons JB 

PROVIDER: S-EPMC9653496 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature