Structural imaging studies of patients with chronic pain: an anatomical likelihood estimate meta-analysis.

ABSTRACT:

Abstract

Neuroimaging is a powerful tool to investigate potential associations between chronic pain and brain structure. However, the proliferation of studies across diverse chronic pain syndromes and heterogeneous results challenges data integration and interpretation. We conducted a preregistered anatomical likelihood estimate meta-analysis on structural magnetic imaging studies comparing patients with chronic pain and healthy controls. Specifically, we investigated a broad range of measures of brain structure as well as specific alterations in gray matter and cortical thickness. A total of 7849 abstracts of experiments published between January 1, 1990, and April 26, 2021, were identified from 8 databases and evaluated by 2 independent reviewers. Overall, 103 experiments with a

SUBMITTER: Henn AT 

PROVIDER: S-EPMC9653511 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature