Nonalcoholic fatty liver disease risk and histologic severity are associated with genetic polymorphisms in children.

ABSTRACT:

Background and aims

NAFLD is the most common chronic liver disease in children. Large pediatric studies identifying single nucleotide polymorphisms (SNPs) associated with risk and histologic severity of NAFLD are limited. Study aims included investigating SNPs associated with risk for NAFLD using family trios and association of candidate alleles with histologic severity.

Approach and results

Children with biopsy-confirmed NAFLD were enrolled from the NASH Clinical Research Network. The Expert Pathology Committee reviewed liver histology. Genotyping was conducted with allele-specific primers for 60 candidate SNPs. Parents were enrolled for trio analysis. To assess risk for NAFLD, the transmission disequilibrium test was conducted in trios. Among cases, regression analysis ass

SUBMITTER: Goyal NP 

PROVIDER: S-EPMC9653518 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature