Dual-Functionalized Nanoliposomes Achieve a Synergistic Chemo-Phototherapeutic Effect.

ABSTRACT: The enhancement of photodynamic therapy (PDT) effectiveness by combining it with other treatment modalities and improved drug delivery has become an interesting field in cancer research. We have prepared and characterized nanoliposomes containing the chemotherapeutic drug irinotecan (CPT11_lip), the photodynamic agent protoporphyrin IX (PpIX_lip), or their combination (CPT11-PpIX_lip). The effects of individual and bimodal (chemo-phototherapeutic) treatments on HeLa cells have been studied by a combination of biological and photophysical studies. Bimodal treatments show synergistic cytotoxic effects on HeLa cells at relatively low doses of PpIX/PDT and CPT11. Mechanistic cell inactivation studies revealed mitotic catastrophe, apoptosis, and senescence contribu

SUBMITTER: Lazaro-Carrillo A 

PROVIDER: S-EPMC9653560 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature