Ent-Abietane Diterpenoids from Euphorbia fischeriana and Their Cytotoxic Activities.

ABSTRACT: The roots of Euphorbia fischeriana have been used as a traditional Chinese medicine for the treatment of tuberculosis and ringworm. In the current study, diterpenoids from the ethyl acetate extract of the roots E. fischeriana and their cytotoxic effects against five cancer lines were investigated. Two new ent-abietane diterpenoids, euphonoids H and I (1-2), as well as their two analogues (3-4) were first isolated from this source. The structures of the two new compounds were elucidated on the basis of spectroscopic data and quantum chemical calculation. Their absolute configurations were assigned via ECD spectrum calculation. The isolated compounds were evaluated for their antiproliferative activities against five cancer cell lines. Compound

SUBMITTER: Zhu QF 

PROVIDER: S-EPMC9653608 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature