Genetic Aspects of Age-Related Macular Degeneration and Their Therapeutic Potential.

ABSTRACT: Age-related macular degeneration (AMD) is a complex and multifactorial disease, resulting from the interaction of environmental and genetic factors. The continuous discovery of associations between genetic polymorphisms and AMD gives reason for the pivotal role attributed to the genetic component to its development. In that light, genetic tests and polygenic scores have been created to predict the risk of development and response to therapy. Still, none of them have yet been validated. Furthermore, there is no evidence from a clinical trial that the determination of the individual genetic structure can improve treatment outcomes. In this comprehensive review, we summarize the polymorphisms of the main pathogenetic ways involved in AMD development to identify which of them constitutes a pot

SUBMITTER: Stradiotto E 

PROVIDER: S-EPMC9653831 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature