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CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A_2A Receptor-Mediated Control of Fear Memory and Amygdala Plasticity.

ABSTRACT: Adenosine A_2A receptors (A_2AR) control fear memory and the underlying processes of synaptic plasticity in the amygdala. In other brain regions, A_2AR activation is ensured by ATP-derived extracellular adenosine formed by ecto-5'-nucleotidase or CD73. We now tested whether CD73 is also responsible to provide for the activation of A_2AR in controlling fear memory and amygdala long-term potentiation (LTP). The bilateral intracerebroventricular injection of the CD73 inhibitor αβ-methylene ADP (AOPCP, 1 nmol/ventricle/day) phenocopied the effect of the A_2AR blockade by decreasing the expression of fear memory, an effect disappearing in CD73-knockout (KO) mice and in forebrain neuronal A_2AR-KO mice. In the presence of PPADS (20 μM)

SUBMITTER: Simoes AP

PROVIDER: S-EPMC9653840 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A_2A Receptor-Mediated Control of Fear Memory and Amygdala Plasticity.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A2A Receptor-Mediated Control of Fear Memory and Amygdala Plasticity.

OmicsDI is part of the ELIXIR infrastructure

Tweets

CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A_2A Receptor-Mediated Control of Fear Memory and Amygdala Plasticity.