PRP8-Induced CircMaml2 Facilitates the Healing of the Intestinal Mucosa via Recruiting PTBP1 and Regulating Sec62.

ABSTRACT:

Background

Multiple organ dysfunction syndrome (MODS) occurs in the gastrointestinal tract and injured intestinal mucosa is the anatomical basis for various diseases. The expression of circular RNAs (circRNAs) is implicated in many diseases; however, the role of circRNAs in intestinal mucosal injury is yet to be discovered. Our preliminary gene microarray analysis revealed a novel circular RNA, circMaml2, with a significant intestinal mucosal protection effect. Its expression was found to decrease in severely burned intestinal mucosal tissue, whereas its overexpression might facilitate the reconstruction of the injured intestinal mucous membrane.

Methods

The function of circMaml2 in cell proliferation and migration was studied in MC38 cells. The repair function of circMaml2

SUBMITTER: Deng Y 

PROVIDER: S-EPMC9654005 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature