Molecular Targeting of the Most Functionally Complex Gene in Precision Oncology: p53.

ABSTRACT: While chemotherapy is a key treatment strategy for many solid tumors, it is rarely curative, and most tumor cells eventually become resistant. Because of this, there is an unmet need to develop systemic treatments that capitalize on the unique mutational landscape of each patient's tumor. The most frequently mutated protein in cancer, p53, has a role in nearly all cancer subtypes and tumorigenesis stages and therefore is one of the most promising molecular targets for cancer treatment. Unfortunately, drugs targeting p53 have seen little clinical success despite promising preclinical data. Most of these drug compounds target specific aspects of p53 inactivation, such as through inhibiting negative regulation by the mouse double minute (MDM) family of proteins. These treatment strategies fai

SUBMITTER: Brown DW 

PROVIDER: S-EPMC9654076 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature