Panel Sequencing of Primary Cutaneous B-Cell Lymphoma.

ABSTRACT:

Background

Primary cutaneous follicular B-cell lymphoma (PCFBCL) represents an indolent subtype of Non-Hodgkin's lymphomas, being clinically characterized by slowly growing tumors of the skin and common cutaneous relapses, while only exhibiting a low propensity for systemic dissemination or fatal outcome. Up to now, only few studies have investigated underlying molecular alterations of PCFBCL with respect to somatic mutations.

Objectives

Our aim was to gain deeper insight into the pathogenesis of PCFBCL and to delineate discriminatory molecular features of this lymphoma subtype.

Methods

We performed hybridization-based panel sequencing of 40 lymphoma-associated genes of 10 cases of well-characterized PCFBCL. In addition, we included two further ambiguous cases of atyp

SUBMITTER: Wobser M 

PROVIDER: S-EPMC9654082 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature