Long-Term Protein Restriction Modulates Lipid Metabolism in White Adipose Tissues and Alters Colonic Microbiota of Shaziling Pigs.

ABSTRACT: Obesity is a matter of concern to the public. Abundant evidence has been accumulated that nutritional intervention is a promising strategy to address this health issue. The objective of this study is to investigate alterations in the lipid metabolism in white adipose tissues and the gut microbiota of Shaziling pigs challenged by long-term protein restriction. Results showed that compared with the control group, reducing the protein level by 20% (-20%) increased the mRNA abundance of FABP4 in white adipose tissues (p < 0.05). This occurred in conjunction with increases in PPARγ protein expression. Conversely, the protein expression of C/EBPα was reduced in the -20% group (p < 0.05). Moreover, the -20% group had increased/decreased phosphorylation of AMPKα/mTOR, respectiv

SUBMITTER: Zheng J 

PROVIDER: S-EPMC9654241 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature