Nna1, Essential for Purkinje Cell Survival, Is also Associated with Emotion and Memory.

ABSTRACT: Nna1/CCP1 is generally known as a causative gene for a spontaneous autosomal recessive mouse mutation, Purkinje cell degeneration (pcd). There is enough evidence that the cytosolic function of the zinc carboxypeptidase (CP) domain at the C-terminus of the Nna1 protein is associated with cell death. On the other hand, this molecule's two nuclear localization signals (NLSs) suggest some other functions exist. We generated exon 3-deficient mice (Nna1^N KO), which encode a portion of the N-terminal NLS. Despite the frameshift occurring in these mice, there was an expression of the Nna1 protein lacking the N-terminal side. Surprisingly, the pcd phenotype did not occur in the Nna1^N KO mouse. Behavioral analysis revealed that they were less

SUBMITTER: Zhou L 

PROVIDER: S-EPMC9654422 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature