A New Model of Acute Exacerbation of Experimental Pulmonary Fibrosis in Mice.

ABSTRACT:

Rationale

idiopathic pulmonary fibrosis (IPF) is the most severe form of fibrosing interstitial lung disease, characterized by progressive respiratory failure leading to death. IPF's natural history is heterogeneous, and its progression unpredictable. Most patients develop a progressive decline of respiratory function over years; some remain stable, but others present a fast-respiratory deterioration without identifiable cause, classified as acute exacerbation (AE).

Objectives

to develop and characterize an experimental mice model of lung fibrosis AE, mimicking IPF-AE at the functional, histopathological, cellular and molecular levels.

Methods

we established in C57BL/6 male mice a chronic pulmonary fibrosis using a repetitive low-dose bleomycin (BLM) intratracheal (IT

SUBMITTER: Yegen CH 

PROVIDER: S-EPMC9654438 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature