Transcriptomic Analysis in Human 3D Skin Model Injected with Resorbable Hyaluronic Acid Fillers Reveals Foreign Body Response.

ABSTRACT: Usage of injectable dermal fillers applied for aesthetic purposes has extensively increased over the years. As such, the number of related adverse reactions has increased, including patients showing severe complications such as product migration, topical swelling and inflammatory reactions of the skin. In order to understand the underlying molecular events of these adverse reactions we performed a genome-wide gene expression study on the multi-cell type human Phenion^® Full-Thickness Skin Model exposed to five experimental hyaluronic acid (HA) preparations with increasing cross-linking degree, four commercial fillers from Perfectha^®, and non-resorbable filler Bio-Alcamid^®. In addition, we evaluated whether cross-linking degree or particle size of the HA-base

SUBMITTER: Jennen DGJ 

PROVIDER: S-EPMC9654658 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature