Identification and Verification of a Novel MAGI2-AS3/miRNA-374-5p/FOXO1 Network Associated with HBV-Related HCC.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a very common neoplasm worldwide, and competitive endogenous RNA (ceRNA) plays an important role in the development of HCC. The purpose of this study is to investigate the molecular mechanisms of ceRNAs in HCC.

Methods

This study detects potential ceRNAs from HCC through whole genome analysis of lncRNA, miRNA and mRNA expression. We then performed high-throughput sequencing of tissues from five hepatitis B related HCC patients to screen ceRNAs and those screened ceRNAs expressions were verified on tissues from an independent group of six patients. Finally, the function of ceRNAs of interest was illustrated in vitro.

Result

Functional and pathway analysis of The Cancer Genome Atlas revealed ceRNA networks. The high-throughpu

SUBMITTER: Wang C 

PROVIDER: S-EPMC9654666 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature