Transcriptomic Studies of Antidepressant Action in Rodent Models of Depression: A First Meta-Analysis.

ABSTRACT: Antidepressants (ADs) are, for now, the best everyday treatment we have for moderate to severe major depressive episodes (MDEs). ADs are among the most prescribed drugs in the Western Hemisphere; however, the trial-and-error prescription strategy and side-effects leave a lot to be desired. More than 60% of patients suffering from major depression fail to respond to the first AD they are prescribed. For those who respond, full response is only observed after several weeks of treatment. In addition, there are no biomarkers that could help with therapeutic decisions; meanwhile, this is already true in cancer and other fields of medicine. For years, many investigators have been working to decipher the underlying mechanisms of AD response. Here, we provide the first systematic review of animal

SUBMITTER: Ibrahim EC 

PROVIDER: S-EPMC9654684 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature