Oxidative Stress Response in Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells.

ABSTRACT: Reactive oxygen species (ROS) can irreversibly damage biological molecules, a process known as oxidative stress. Elevated ROS levels are associated with immune cell activation. Sustained immune system activation can affect many different cells in the environment. One cell type that has been detected in almost all tissues of the body is mesenchymal stem/stromal cells (MSC). MSC possess proliferation and differentiation potential, thus facilitating regeneration processes. However, the regenerative capacity of MSC might be impaired by oxidative stress, and the effects of long-term oxidative stress on MSC functions are sparsely described. The examination of oxidative stress is often performed by exposure to H₂O₂. Since H₂O₂ is rapidly degraded, we ad

SUBMITTER: Waheed TO 

PROVIDER: S-EPMC9654835 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature