Effects of Selenium on Chronic Kidney Disease: A Mendelian Randomization Study.

ABSTRACT:

Background

Previous observational studies have shown that there is a controversial association between selenium levels and chronic kidney disease (CKD). Our aim was to assess the causal relationship between selenium levels and CKD using Mendelian randomization (MR) analysis.

Methods

We used the two-sample Mendelian randomization (MR) method to analyze the causal role of selenium levels on CKD risk. The variants associated with selenium levels were extracted from a large genome-wide association study (GWAS) meta-analysis of circulating selenium levels (n = 5477) and toenail selenium levels (n = 4162) in the European population. Outcome data were from the largest GWAS meta-analysis of European-ancestry participants for kidney function to date. Inverse variance we

SUBMITTER: Fu S 

PROVIDER: S-EPMC9654848 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature