Role of Non-Coding RNAs in Colorectal Cancer: Focus on Long Non-Coding RNAs.

ABSTRACT: Colorectal cancer is one of the most common causes of cancer-related deaths worldwide. Despite the advances in the knowledge of pathogenetic molecular mechanisms and the implementation of more effective drug treatments in recent years, the overall survival rate of patients remains unsatisfactory. The high death rate is mainly due to metastasis of cancer in about half of the cancer patients and the emergence of drug-resistant populations of cancer cells. Improved understanding of cancer molecular biology has highlighted the role of non-coding RNAs (ncRNAs) in colorectal cancer development and evolution. ncRNAs regulate gene expression through various mechanisms, including epigenetic modifications and interactions of long non-coding RNAs (lncRNAs) with both microRNAs (miRNAs) and proteins, a

SUBMITTER: Lulli M 

PROVIDER: S-EPMC9654895 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature