The Hidden Role of Non-Canonical Amyloid β Isoforms in Alzheimer's Disease.

ABSTRACT: Recent advances have placed the pro-inflammatory activity of amyloid β (Aβ) on microglia cells as the focus of research on Alzheimer's Disease (AD). Researchers are confronted with an astonishing spectrum of over 100 different Aβ variants with variable length and chemical modifications. With the exception of Aβ_1-42 and Aβ_1-40, the biological significance of most peptides for AD is as yet insufficiently understood. We therefore aim to provide a comprehensive overview of the contributions of these neglected Aβ variants to microglia activation. First, the impact of Aβ receptors, signaling cascades, scavenger mechanisms, and genetic variations on the physiological responses towards various Aβ species is described. Furthermore, we discuss the importance of different types

SUBMITTER: Busch L 

PROVIDER: S-EPMC9654995 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature