Interaction of Influenza A Nucleoprotein with Host hnRNP-C Is Implicated in Viral Replication.

ABSTRACT: The host interactome of influenza viral proteins is ever-expanding. In this work, we report the identification of host heterogeneous nuclear ribonucleoprotein C (hnRNP-C) as an interacting partner of influenza A virus nucleoprotein (NP). We confirmed that this interaction exists across different influenza A subtypes and strains. Using biochemical methods, we determined that hnRNP-C interacts with NP via its C-terminal auxiliary domain. Further, we determined that the hnRNP-C is a negative regulator of influenza viral growth. Its interaction with NP is implicated in the promotion of host cell apoptosis during viral infection. It is the first time that the interaction between influenza nucleoprotein and host heterogeneous nuclear ribonucleoprotein C is characterized in detail. Overall, these

SUBMITTER: Tang YS 

PROVIDER: S-EPMC9655074 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature