Salmonella typhimurium encodes a putative iron transport system within the centisome 63 pathogenicity island.

ABSTRACT: Upon entry into the host, Salmonella enterica strains are presumed to encounter an iron-restricted environment. Consequently, these bacteria have evolved a variety of often-redundant high-affinity acquisition systems to obtain iron in this restricted environment. We have identified an iron transport system that is encoded within the centisome 63 pathogenicity island of Salmonella typhimurium. The nucleotide composition of this locus is significantly different from that of the rest of this pathogenicity island, suggesting a different ancestry and a mosaic structure for this region of the S. typhimurium chromosome. This locus, designated sit, consists of four open reading frames which encode polypeptides with extensive homology to the yfe ABC iron transport system of Yersinia pestis, as well

SUBMITTER: Zhou D 

PROVIDER: S-EPMC96555 | biostudies-literature | 1999 Apr

REPOSITORIES: biostudies-literature