Analysis of Bone Histomorphometry in Rat and Guinea Pig Animal Models Subject to Hypoxia.

ABSTRACT: Hypoxia may be associated with alterations in bone remodeling, but the published results are contradictory. The aim of this study was to characterize the bone morphometry changes subject to hypoxia for a better understanding of the bone response to hypoxia and its possible clinical consequences on the bone metabolism. This study analyzed the bone morphometry parameters by micro-computed tomography (μCT) in rat and guinea pig normobaric hypoxia models. Adult male and female Wistar rats were exposed to chronic hypoxia for 7 and 15 days. Additionally, adult male guinea pigs were exposed to chronic hypoxia for 15 days. The results showed that rats exposed to chronic constant and intermittent hypoxic conditions had a worse trabecular and cortical bone health than control rats (under a normoxic

SUBMITTER: Usategui-Martin R 

PROVIDER: S-EPMC9655516 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature