Role of SALL4 in HER2+ Breast Cancer Progression: Regulating PI3K/AKT Pathway.

ABSTRACT: Treatment for the HER2+ breast cancer subtype is still unsatisfactory, despite breakthroughs in research. The discovery of various new molecular mechanisms of transcription factors may help to make treatment regimens more effective. The transcription factor SALL4 has been related to aggressiveness and resistance therapy in cancer. Its molecular mechanisms and involvement in various signaling pathways are unknown in the HER2+ breast cancer subtype. In this study, we have evaluated the implication of SALL4 in the HER2+ subtype through its expression in patients' samples and gain and loss of function in HER2+ cell lines. We found higher SALL4 expression in breast cancer tissues compared to healthy tissue. Interestingly, high SALL4 expression was associated with disease relapse and poor patien

SUBMITTER: Pattanayak B 

PROVIDER: S-EPMC9655635 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature