Programmed death ligand 1 and tumor-infiltrating CD8⁺ T lymphocytes are associated with the clinical features in meningioma.

ABSTRACT:

Objective

To investigate the expression of programmed death ligand-1 (PD-L1) and the levels of CD8⁺ tumor-infiltrating lymphocytes (TILs) in meningioma as well as determine the association between their levels and the clinical outcomes.

Methods

We performed a retrospective case-control study on 93 patients with meningioma. The patients showed tumor recurrence and were matched with the control patients without recurrence in their age, gender, admission time, tumor sites, tumor volume, peritumoral brain edema (PTBE), Simpson grade resection, WHO grade, postoperative radiotherapy, and the follow-up duration. We reviewed the clinical data of patients and performed immunohistochemistry analysis to investigate the PD-L1 expression and the levels of CD8⁺ TILs.

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9655806 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature