Identification of MYEOV-Associated Gene Network as a Potential Therapeutic Target in Pancreatic Cancer.

ABSTRACT: The molecular mechanism that promotes pancreatic cancer remains unclear, so it is important to find the molecular network of important genes related to pancreatic cancer. To find the key molecule of pancreatic cancer, differential gene expression analyses were analyzed by the Deseq2 package, edgeR package, and limma-voom package, respectively. Pancreatic cancer survival-related genes were analyzed by COX survival analysis. Finally, we integrated the results to obtain the significantly differentially expressed gene, MYEOV (myeloma overexpressed gene), most strongly related to survival in pancreatic cancer. Experimental verification by qRT-PCR confirmed that transcription levels of MYEOV mRNA markedly increased in pancreatic cancer cells relative to normal human pancreatic ductal epithelial

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9655857 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature