Assessing the In Vivo Biocompatibility of Molecularly Imprinted Polymer Nanoparticles.

ABSTRACT: Molecularly imprinted polymer nanoparticles (nanoMIPs) are high affinity synthetic receptors which show promise as imaging and therapeutic agents. Comprehensive analysis of the in vivo behaviour of nanoMIPs must be performed before they can be considered for clinical applications. This work reports the solid-phase synthesis of nanoMIPs and an investigation of their biodistribution, clearance and cytotoxicity in a rat model following both intravenous and oral administration. These nanoMIPs were found in each harvested tissue type, including brain tissue, implying their ability to cross the blood-brain barrier. The nanoMIPs were cleared from the body via both faeces and urine. Furthermore, we describe an immunogenicity study in mice, demonstrating that nanoMIPs specific for a cell surface pr

SUBMITTER: Kassem S 

PROVIDER: S-EPMC9655879 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature