Scoping Review on Platelets and Tumor Angiogenesis: Do We Need More Evidence or Better Analysis?

ABSTRACT: Platelets are an active component of the tumor microenvironment (TME), involved in the regulation of multiple tumor processes, including angiogenesis. They are generated rich in angiogenic factors in their granules to actively participate in the hemostatic process by megakaryocytes and further enriched in angiogenic factors by all components of the tumor microenvironment to control the angiogenic process because of their preferential relationship with the endothelial component of vessels. In recent decades, the literature has reported a great deal of evidence on the role of platelets in tumor angiogenesis; however, it is unclear whether the number or mean volume of platelets and/or their content and localization in TME may have clinical relevance in the choice and management of therapy for

SUBMITTER: Filippelli A 

PROVIDER: S-EPMC9656254 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature