Midbody Proteins Display Distinct Dynamics during Cytokinesis.

ABSTRACT: The midbody is an organelle that forms between the two daughter cells during cytokinesis. It co-ordinates the abscission of the nascent daughter cells and is composed of a multitude of proteins that are meticulously arranged into distinct temporal and spatial localization patterns. However, very little is known about the mechanisms that regulate the localization and function of midbody proteins. Here, we analyzed the temporal and spatial profiles of key midbody proteins during mitotic exit under normal conditions and after treatment with drugs that affect phosphorylation and proteasome-mediated degradation to decipher the impacts of post-translational modifications on midbody protein dynamics. Our results highlighted that midbody proteins show distinct spatio-temporal dynamics during mitot

SUBMITTER: Halcrow EFJ 

PROVIDER: S-EPMC9656288 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature