Accurate Characterization of Bladder Cancer Cells with Intraoperative Flow Cytometry.

ABSTRACT: Bladder cancer represents a major health issue. Transurethral resection is the first line treatment and an accurate assessment of tumor margins might warrant complete tumor removal. Genomic instability and proliferative potential are common hallmarks of cancer cells. We have previously demonstrated the utility of intraoperative flow cytometry (iFC), a next-generation margin evaluation methodology for assessment of DNA content, in the detection of several types of malignancy. In the current study we investigated the possible value of iFC in the characterization of bladder cancer during surgery. Samples from a population of 52 people with urothelial cancer were included in the study. The total time for iFC evaluation is 3-5 min per sample and included a two-step analysis, including DNA-index

SUBMITTER: Paliouras A 

PROVIDER: S-EPMC9656620 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature