Clinical Study of the Relationship between Sjogren Syndrome and T-Cell Large Granular Lymphocytic Leukemia: Single-Center Experience.

ABSTRACT: The relationship between Sjögren syndrome (SS) and T-cell large granular lymphocytic (T-LGL) leukemia remains unclear. In this paper, we report for the first time a large case series of 21 patients with primary and secondary SS associated with T-LGL leukemia. Our results suggest the importance of considering T-LGL leukemia in the diagnostic evaluation of SS patients, particularly when neutropenia occurs. We also postulate that elevated antinuclear antibody titers in patients with T-LGL leukemia indicate the need for the clinical assessment of SS. To assess whether SS affects the frequency of the signal transducer and activator of transcription 3 (STAT3) gene mutations in T-LGL leukemia, we examined STAT3 mutations by next-generation sequencing in two cohorts of patients: with

SUBMITTER: Gorodetskiy V 

PROVIDER: S-EPMC9656665 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature