Does Generic Cyclic Kinase Insert Domain of Receptor Tyrosine Kinase KIT Clone Its Native Homologue?

ABSTRACT: Receptor tyrosine kinases (RTKs) are modular membrane proteins possessing both well-folded and disordered domains acting together in ligand-induced activation and regulation of post-transduction processes that tightly couple extracellular and cytoplasmic events. They ensure the fine-turning control of signal transmission by signal transduction. Deregulation of RTK KIT, including overexpression and gain of function mutations, has been detected in several human cancers. In this paper, we analysed by in silico techniques the Kinase Insert Domain (KID), a key platform of KIT transduction processes, as a generic macrocycle (KID^GC), a cleaved isolated polypeptide (KID^C), and a natively fused TKD domain (KID^D). We assumed that these KID species have similar struct

SUBMITTER: Ledoux J 

PROVIDER: S-EPMC9656684 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature