Nitrate in Maternal Drinking Water during Pregnancy and Measures of Male Fecundity in Adult Sons.

ABSTRACT: Animal studies indicate deleterious effects of nitrate exposure on fecundity, but effects in humans are unknown, both for the prenatal and postnatal periods. We aimed to investigate if exposure to nitrate in maternal drinking water during the sensitive period of fetal life is associated with measures of fecundity in the adult sons. In a sub-analysis, the potential effects of nitrate exposure in adulthood were investigated. This cohort included 985 young adult men enrolled in The Fetal Programming of Semen Quality Cohort (FEPOS). Semen characteristics, testes volume and reproductive hormones were analyzed in relation to nitrate concentration in maternal drinking water, using a negative binomial regression model. The nitrate concentration in drinking water was obtained from monitoring data f

SUBMITTER: Clemmensen PJ 

PROVIDER: S-EPMC9656746 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature