Catalytically Active Amyloids as Future Bionanomaterials.

ABSTRACT: Peptides and proteins can aggregate into highly ordered and structured conformations called amyloids. These supramolecular structures generally have convergent features, such as the formation of intermolecular beta sheets, that lead to fibrillary architectures. The resulting fibrils have unique mechanical properties that can be exploited to develop novel nanomaterials. In recent years, sequences of small peptides have been rationally designed to self-assemble into amyloids that catalyze several chemical reactions. These amyloids exhibit reactive surfaces that can mimic the active sites of enzymes. In this review, I provide a state-of-the-art summary of the development of catalytically active amyloids. I will focus especially on catalytic activities mediated by hydrolysis, which are the mos

SUBMITTER: Diaz-Espinoza R 

PROVIDER: S-EPMC9656882 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature