The Riddle of Cetuximab-Related Skin Toxicity: ¹H-NMR Sebum Analysis Revealed Dynamic Lipid Alterations Associated with Skin Toxicity Development in Metastatic Colorectal Cancer Patients.

ABSTRACT: The epidermal growth factor receptor inhibitor (EGFRIs) treatments are commonly associated with the development of adverse skin effects. This study aims to investigate the lipid composition change in sebum during cetuximab-based treatment in an attempt to identify specific metabolic signatures useful in predicting the occurrence of severe skin toxicity. Sebum from 30 metastatic colorectal cancer (mCRC) patients was collected at three time points during the targeted therapy by the application of Sebutape^® on the forehead, and the major lipid classes were analyzed and quantified by ¹H-NMR. Univariate analysis was performed to reveal significant alterations among patients in sebum production as well as lipid composition and over the course of cetuximab therapy. A transie

SUBMITTER: Saorin A 

PROVIDER: S-EPMC9656910 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature