Radiochemical Feasibility of Mixing of ^99mTc-MAA and ⁹⁰Y-Microspheres with Omnipaque Contrast.

ABSTRACT: Yttrium-90 (⁹⁰Y) microspheres are widely used for the treatment of liver-dominant malignant tumors. They are infused via catheter into the hepatic artery branches supplying the tumor under fluoroscopic guidance based on pre-therapy angiography and Technetium-99m macroaggregated albumin (^99mTc-MAA) planning. However, at present, these microspheres are suspended in radiolucent media such as dextrose 5% (D5) solution. In order to monitor the real-time implantation of the microspheres into the tumor, the ⁹⁰Y microspheres could be suspended in omnipaque contrast for allowing visualization of the correct distribution of the microspheres into the tumor. The radiochemical purity of mixing ⁹⁰Y-microspheres in various concentrations of omnipaque was invest

SUBMITTER: Yang CT 

PROVIDER: S-EPMC9656951 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature