Evaluating EcxR for Its Possible Role in Ehrlichia chaffeensis Gene Regulation.

ABSTRACT: Ehrlichia chaffeensis, a tick-transmitted intraphagosomal bacterium, is the causative agent of human monocytic ehrlichiosis. The pathogen also infects several other vertebrate hosts. E. chaffeensis has a biphasic developmental cycle during its growth in vertebrate monocytes/macrophages and invertebrate tick cells. Host- and vector-specific differences in the gene expression from many genes of E. chaffeensis are well documented. It is unclear how the organism regulates gene expression during its developmental cycle and for its adaptation to vertebrate and tick host cell environments. We previously mapped promoters of several E. chaffeensis genes which are recognized by its only two sigma factors: σ³² and σ⁷⁰. In the current study, we investi

SUBMITTER: Liu H 

PROVIDER: S-EPMC9657007 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature