Different Requirements of CBFB and RUNX2 in Skeletal Development among Calvaria, Limbs, Vertebrae and Ribs.

ABSTRACT: RUNX proteins, such as RUNX2, regulate the proliferation and differentiation of chondrocytes and osteoblasts. Haploinsufficiency of RUNX2 causes cleidocranial dysplasia, but a detailed analysis of Runx2^+/- mice has not been reported. Furthermore, CBFB is required for the stability and DNA binding of RUNX family proteins. CBFB has two isoforms, and CBFB2 plays a major role in skeletal development. The calvaria, femurs, vertebrae and ribs in Cbfb2^-/- mice were analyzed after birth, and compared with those in Runx2^+/- mice. Calvarial development was impaired in Runx2^+/- mice but mildly delayed in Cbfb2^-/- mice. In femurs, the cortical bone but not trabecular bone was reduced in Cbfb2^-/

SUBMITTER: Jiang Q 

PROVIDER: S-EPMC9657020 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature