Entropy-Driven Inclusion of Natural Protoberberine Alkaloids in Sulfobutylether-β-Cyclodextrin.

ABSTRACT: The understanding of the relationship between molecular structure and the thermodynamics of host-guest binding is essential for the rational design of the applications of inclusion complexes. To obtain insight into the factors governing the driving force of complex formation in aqueous solutions, the encapsulation of five pharmaceutically important protoberberine alkaloids was studied in sulfobutylether-β-cyclodextrin having on average 6.4 degrees of substitution (SBE_6.4βCD). Spectrophotometric, fluorescence spectroscopic, and isothermal calorimetric measurements showed 1:1 complexation in dilute solutions. From 1.92 × 10⁴ M^-1, about an eight-fold decrease of the association constant was observed in the series of berberine ≈ coptisine >> palmatine >

SUBMITTER: Miskolczy Z 

PROVIDER: S-EPMC9657192 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature